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Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila.

ABSTRACT: The repeated and improper use of antibiotics had led to an increased number of multiresistant bacteria. Therefore, new lead structures are needed. Here, the synthesis and an expanded structure-activity relationship of the simple and antistaphylococcal amide nematophin from Xenorhabdus nematophila and synthetic derivatives are described. Moreover, the synthesis of intrinsic fluorescent derivatives, incorporating azaindole moieties was achieved for the first time.

SUBMITTER: Wesche F

PROVIDER: S-EPMC6404511 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila.

Wesche Frank F Adihou Hélène H Wichelhaus Thomas A TA Bode Helge B HB

Beilstein journal of organic chemistry 20190225

The repeated and improper use of antibiotics had led to an increased number of multiresistant bacteria. Therefore, new lead structures are needed. Here, the synthesis and an expanded structure-activity relationship of the simple and antistaphylococcal amide nematophin from Xenorhabdus nematophila and synthetic derivatives are described. Moreover, the synthesis of intrinsic fluorescent derivatives, incorporating azaindole moieties was achieved for the first time. ...[more]

PMID: 30873237

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