Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer.

ABSTRACT:

Purpose

Multiple aspects of the tumor microenvironment (TME) impact breast cancer, yet the genetic modifiers of the TME are largely unknown, including those that modify tumor vascular formation and function.

Methods

To discover host TME modifiers, we developed a system called the Consomic/Congenic Xenograft Model (CXM). In CXM, human breast cancer cells are orthotopically implanted into genetically engineered consomic xenograft host strains that are derived from two parental strains with different susceptibilities to breast cancer. Because the genetic backgrounds of the xenograft host strains differ, whereas the inoculated tumor cells are the same, any phenotypic variation is due to TME-specific modifier(s) on the substituted chromosome (consomic) or subchromosomal region (c

SUBMITTER: Flister MJ 

PROVIDER: S-EPMC6404538 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature