The RNA-binding protein LIN28 controls progenitor and neuronal cell fate during postnatal neurogenesis.

ABSTRACT: The RNA-binding protein LIN28 is known to regulate cell fate, tissue growth, and pluripotency; however, a unified understanding of its role at the cellular level has not been achieved. Here, we address its developmental activity in mammalian postnatal neurogenesis. Constitutive expression of LIN28 in progenitor cells of the mouse subventricular zone (SVZ) caused several distinct effects: 1) the number of differentiated neurons in the olfactory bulb was dramatically reduced, whereas the relative abundance of 2 neuronal subtypes was significantly altered, 2) the population of proliferating neural progenitors in the SVZ was reduced, whereas the proportion of neuroblasts was increased, and 3) the number of astrocytes was reduced, occasionally causing them to appear early. Thus, LIN28 acts at a

SUBMITTER: Romer-Seibert JS 

PROVIDER: S-EPMC6404560 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature