Turning Observed Founder Alleles into Expected Relationships in an Intercross Population.

ABSTRACT: Pedigree-derived relationships for individuals from an intercross of several lines cannot easily account for the segregation variance that is mainly caused by loci with alternative alleles fixed in different lines. However, when all founders are genotyped for a large number of markers, such relationships can be derived for descendants as expected genomic relationships conditional on the observed founder allele frequencies. A tabular method was derived in detail for autosomes and the X-chromosome. As a case study, we analyzed litter size and body weights at three different ages in an advanced mouse intercross (29 generations, total pedigree size 19,266) between a line selected for high litter size (FL1) and a highly inbred control line (DUKsi). Approximately 60% of the total genetic varianc

SUBMITTER: Meng J 

PROVIDER: S-EPMC6404597 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature