Genetic Effects on Dispersion in Urinary Albumin and Creatinine in Three House Mouse (Mus musculus) Cohorts.

ABSTRACT: Conventionally, quantitative genetics concerns the heredity of trait means, but there is growing evidence for the existence of architectures in which certain alleles cause random variance in phenotype, termed 'phenotypic dispersion' (PD) or 'variance QTL' (vQTL), including in physiological traits like disease signs. However, the structure of this phenomenon is still poorly known. PD for urinary albumin (PD_UAlb ) and creatinine (PD_UCrea ) was mapped using curated data from two nearly genetically identical F₂ mouse (Mus musculus) cohorts (383 male F₂ C57BL/6J×A/J (97 SNP) and 207 male F₂ C57BL/6J×A/J ApoE knockout mice (144 SNP)) and a related mapping cohort (340 male F₂ DBA/2J×C57BL/6

SUBMITTER: Perry GML 

PROVIDER: S-EPMC6404620 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature