Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women.

ABSTRACT:

Introduction

Possible joint effects of subjective cognitive decline (SCD) and apolipoprotein E (APOE) ε4 genotype on incident mild cognitive impairment (MCI) were examined for men and women separately.

Methods

Cognitively normal participants with and without SCD were included from the first follow-up examination of the population-based Heinz Nixdorf Recall study. Sex-stratified logistic regression models estimated main effects and interactions (additive, multiplicative) of SCD at the first follow-up (yes+/no-) and APOE ε4 (positive+/negative-) groups for MCI 5 years later.

Results

Odds for MCI 5 years later were higher in SCD/APOE ε4 group +/+ than the sum of groups +/- and -/+ in women, with a trend for positive interaction. Odds for incident MCI

SUBMITTER: Muller-Gerards D 

PROVIDER: S-EPMC6404645 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature