Remote Ischemic Preconditioning Acutely Improves Coronary Microcirculatory Function.

ABSTRACT: Background Remote ischemic preconditioning (RIPC) attenuates myocardial damage during elective and primary percutaneous coronary intervention. Recent studies suggest that coronary microcirculatory function is an important determinant of clinical outcome. The aim of this study was to assess the effect of RIPC on markers of microcirculatory function. Methods and Results Patients referred for cardiac catheterization and fractional flow reserve measurement were randomized to RIPC or sham. Operators and patients were blinded to treatment allocation. Comprehensive physiological assessments were performed before and after RIPC/sham including the index of microcirculatory resistance and coronary flow reserve after intracoronary glyceryl trinitrate and during the infusion of intravenous adenosine.

SUBMITTER: Lau JK 

PROVIDER: S-EPMC6404904 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature