Multi-state models of transitions in depression and anxiety symptom severity and cardiovascular events in patients with coronary heart disease.

ABSTRACT:

Objective

Patients with coronary heart disease (CHD) commonly suffer from depression and anxiety, yet transitions of symptom severity and cardiovascular events (CVE) over time are not well characterized.

Methods

We included 997 patients with stable CHD from a prospective cohort study. We estimated 5- and 10-year transition probabilities of depression and anxiety symptom severity levels and fatal- and non-fatal adverse CVE. Depression and anxiety symptoms were measured with the Hospital Anxiety and Depression Scale 5 times over 13 years and categorized as no, mild, or moderate/severe symptoms. Using multi-state modeling, we calculated 5- and 10-year transition probabilities for depression and anxiety symptom severity and CVE and calculated transition intensity ratios for fact

SUBMITTER: Meyer ML 

PROVIDER: S-EPMC6405099 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature