Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk.

ABSTRACT:

Purpose

Several researchers have suggested that the rs243865 (16q13-q21) polymorphism in the promoter region of the metalloproteinase-2 (MMP-2) gene could be associated with an increased risk of developing age-related macular degeneration (AMD). However, previous results remain inconclusive. To clarify this controversy, we conducted a meta-analysis of the relationship between rs243865 of MMP-2 and AMD.

Methods

We included 6 independent case-control studies involving 1,682 AMD patients and 2,295 healthy subjects. The association between the rs243865 polymorphism and AMD was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used a recessive genetic model analysis, sensitivity analysis, and assessment of bias in our meta-analysis.

Results

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SUBMITTER: Usategui-Martin R 

PROVIDER: S-EPMC6405106 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature