Iron, Hepcidin, and Death in Human AKI.

ABSTRACT: BACKGROUND:Iron is a key mediator of AKI in animal models, but data on circulating iron parameters in human AKI are limited. METHODS:We examined results from the ARF Trial Network study to assess the association of plasma catalytic iron, total iron, transferrin, ferritin, free hemoglobin, and hepcidin with 60-day mortality. Participants included critically ill patients with AKI requiring RRT who were enrolled in the study. RESULTS:Of the 807 study participants, 409 (51%) died by day 60. In both unadjusted and multivariable adjusted models, higher plasma concentrations of catalytic iron were associated with a significantly greater risk of death, as were lower concentrations of hepcidin. After adjusting for other factors, patients with catalytic iron levels in the highest quintile versus the

SUBMITTER: Leaf DE 

PROVIDER: S-EPMC6405140 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature