Arginase-II negatively regulates renal aquaporin-2 and water reabsorption.

ABSTRACT: Type-II l-arginine:ureahydrolase, arginase-II (Arg-II), is abundantly expressed in the kidney. The physiologic role played by Arg-II in the kidney remains unknown. Herein, we report that in mice that are deficient in Arg-II (Arg-II^-/-), total and membrane-associated aquaporin-2 (AQP2) protein levels were significantly higher compared with wild-type (WT) controls. Water deprivation enhanced Arg-II expression, AQP2 levels, and membrane association in collecting ducts. Effects of water deprivation on AQP2 were stronger in Arg-II^-/- mice than in WT mice. Accordingly, a decrease in urine volume and an increase in urine osmolality under water deprivation were more pronounced in Arg-II^-/- mice than in WT mice, which correlated with a weaker increase in plasma osmo

SUBMITTER: Huang J 

PROVIDER: S-EPMC6405175 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature