Genetics of Subclinical Coronary Atherosclerosis.

ABSTRACT:

Purpose of review

This review highlights recent findings regarding genetics of coronary artery calcification (CAC), a marker of subclinical atherosclerosis burden, that is a precursor of clinical coronary artery disease.

Recent findings

CAC quantity is heritable. Genome wide association studies of common single nucleotide polymorphisms have identified genomic regions explaining ~2.4% of CAC heritability. Low frequency and rare variants explain additional variation in CAC. Evidence suggests that there may be different genetic etiologies for variation in CAC progression than for cross-sectional measures of CAC. Studies integrating multiple -omics data are providing new insights into the pathobiology of subclinical coronary atherosclerosis.

Summary

The future is promisin

SUBMITTER: Bielak LF 

PROVIDER: S-EPMC6405218 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature