Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future.

ABSTRACT: Type 2 diabetes mellitus (T2D) and obesity already represent 2 of the most prominent risk factors for cardiovascular disease, and are destined to increase in importance given the global changes in lifestyle. Ten years have passed since the first round of genome-wide association studies for T2D and obesity. During this decade, we have witnessed remarkable developments in human genetics. We have graduated from the despair of candidate gene-based studies that generated few consistently replicated genotype-phenotype associations, to the excitement of an exponential harvest of loci robustly associated with medical outcomes through ever larger genome-wide association study meta-analyses. As well as discovering hundreds of loci, genome-wide association studies have provided transformative insight

SUBMITTER: Ingelsson E 

PROVIDER: S-EPMC6405228 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature