Predicting the Impact of Typhoid Conjugate Vaccines on Antimicrobial Resistance.

ABSTRACT:

Background

Empiric prescribing of antimicrobials in typhoid-endemic settings has increased selective pressure on the development of antimicrobial-resistant Salmonella enterica serovar Typhi. The introduction of typhoid conjugate vaccines (TCVs) in these settings may relieve this selective pressure, thereby reducing resistant infections and improving health outcomes.

Methods

A deterministic transmission dynamic model was developed to simulate the impact of TCVs on the number and proportion of antimicrobial-resistant typhoid infections and chronic carriers. One-way sensitivity analyses were performed to ascertain particularly impactful model parameters influencing the proportion of antimicrobial-resistant infections and the proportion of cases averted over 10 years.

Results

SUBMITTER: Kaufhold S 

PROVIDER: S-EPMC6405272 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature