Selected RANKL/RANK/OPG system genetic variants in diabetic foot patients.

ABSTRACT:

Purpose

Diabetic foot is a complication of long-lasting diabetes mellitus affecting up to 15% of patients, both in type 1 and type 2 diabetes. Osteoprotegerin is involved in osteogenesis and calcification. The aim of the study was to assess the role of selected osteoprotegerin gene variants in diabetes patients with diabetic foot.

Methods

The study involved 300 patients with diabetes and diabetic foot and 968 healthy controls. The study group was formed by 243 patients with diabetic foot of neuropathic origin, 102 with diabetic foot of neuroischemic origin and 77 with Charcot neuroarthropathy.

Results

Compared to controls, rs1872426 and rs1485286 showed correlation with diabetic foot in diabetes subjects. Significant associations between rs2073618, rs1872426, rs746449

SUBMITTER: Mrozikiewicz-Rakowska B 

PROVIDER: S-EPMC6405386 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature