Follistatin Effects in Migration, Vascularization, and Osteogenesis in vitro and Bone Repair in vivo.

ABSTRACT: The use of biomaterials and signaling molecules to induce bone formation is a promising approach in the field of bone tissue engineering. Follistatin (FST) is a glycoprotein able to bind irreversibly to activin A, a protein that has been reported to inhibit bone formation. We investigated the effect of FST in critical processes for bone repair, such as cell recruitment, osteogenesis and vascularization, and ultimately its use for bone tissue engineering. In vitro, FST promoted mesenchymal stem cell (MSC) and endothelial cell (EC) migration as well as essential steps in the formation and expansion of the vasculature such as EC tube-formation and sprouting. FST did not enhance osteogenic differentiation of MSCs, but increased committed osteoblast mineralization. In vivo, FST was loaded in an

SUBMITTER: Fahmy-Garcia S 

PROVIDER: S-EPMC6405513 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature