Preconception Exposure to Fine Particulate Matter Leads to Cardiac Dysfunction in Adult Male Offspring.

ABSTRACT: Background Particulate matter (particles < 2.5 μm [ PM _2.5]) exposure during the in utero and postnatal developmental periods causes cardiac dysfunction during adulthood. Here, we investigated the potential priming effects of preconception exposure of PM _2.5 on cardiac function in adult offspring. Methods and Results Male and female friend leukemia virus b (FVB) mice were exposed to either filtered air ( FA ) or PM _2.5 at an average concentration of 38.58 μg/m³ for 6 hours/day, 5 days/week for 3 months. Mice were then crossbred into 2 groups: (1)  FA _male× FA _female (both parents were exposed to FA preconception) and, (2) PM _2.5male× PM _2.5female (both parents were exposed to PM _2.5 preconcep

SUBMITTER: Tanwar V 

PROVIDER: S-EPMC6405597 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature