Autoantibodies Against β₁-Adrenoceptor Exaggerated Ventricular Remodeling by Inhibiting CTRP9 Expression.

ABSTRACT: Background Autoantibodies against the second extracellular loop of the β₁-adrenoceptor (β₁- AA ) act similarly to agonist of β₁-adrenergic receptor, which plays an important role in the pathophysiological characteristics of ventricular remodeling. Recently, considerable lines of evidence have suggested that CTRP9 (C1q tumor necrosis factor-related protein 9) is a potent cardioprotective cardiokine and protects the heart from ventricular remodeling. The aim of this study was to determine the role of CTRP 9 in ventricular remodeling induced by β₁- AA . Methods and Results Blood samples were collected from 131 patients with coronary heart disease and 131 healthy subjects. The serum levels of β₁- AA and CTRP 9 were detected using ELISA . T

SUBMITTER: Du Y 

PROVIDER: S-EPMC6405676 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature