New Molecular Mechanism Underlying Myc-Mediated Cytochrome P450 2E1 Upregulation in Apoptosis and Energy Metabolism in the Myocardium.

ABSTRACT: Background Canonical studies indicate that cytochrome P450 2E1 ( CYP 2E1) plays a critical role in the metabolism of xenobiotics and ultimately participates in tissue damage. CYP 2E1 upregulates in the pathophysiological development of multiple diseases; however, the mechanism of CYP 2E1 upregulation, particularly in heart disease, remains elusive. Methods and Results We found that the level of CYP 2E1 increased in heart tissues from patients with hypertrophic cardiomyopathy; multiple mouse models of heart diseases, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and myocardial ischemia; and HL -1 myocytes under stress. We determined that Myc bound to the CYP 2E1 promoter and activated its transcription by bioinformatics analysis, luciferase activity, and chromatin immunopre

SUBMITTER: Guan F 

PROVIDER: S-EPMC6405704 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature