Src activation in the hypothalamic arcuate nucleus may play an important role in pain hypersensitivity.

ABSTRACT: Src family of kinases (SFKs) has been found to play an important role in the regulation of nociception. However, how each member of this family acts in the central nervous system (CNS) structures involved in the relay and/or modulation of nociceptive signals, and thereby contributes to the formation and maintenance of pain hypersensitivity, is still a challenge. In this work, a combined study using biochemical, genetic and behavioral approaches was conducted. We found that the expression of activated SFKs in the hypothalamic arcuate nucleus (ARC) area was significantly increased following the development of inflammation induced by injection of complete freund's adjuvant (CFA) into the hind paw of rats. Furthermore, we identified that Src, but not Fyn or Lyn in the Src family, was activated

SUBMITTER: Ma H 

PROVIDER: S-EPMC6405746 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature