Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis.

ABSTRACT: Systemic administration of bio-therapeutics can result in only a fraction of drug reaching targeted tissues, with the majority of drug being distributed to tissues irrelevant to the drug's site of action. Targeted delivery to specific organs may allow for greater accumulation, better efficacy, and improved safety. We investigated how targeting plasmalemma vesicle-associated protein (PV1), a protein found in the endothelial caveolae of lungs and kidneys, can promote accumulation in these organs. Using ex vivo fluorescence imaging, we show that intravenously administered αPV1 antibodies localize to mouse lungs and kidneys. In a bleomycin-induced idiopathic pulmonary fibrosis (IPF) mouse model, αPV1 conjugated to Prostaglandin E₂ (PGE₂), a known anti-fibrotic agent, sign

SUBMITTER: Marchetti GM 

PROVIDER: S-EPMC6405929 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature