P38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury.

ABSTRACT: p38α MAPK negatively regulates the G₁/S and G₂/M cell cycle transitions. However, liver-specific p38α deficiency impairs cytokinesis and reduces hepatocyte proliferation during cirrhosis and aging in mice. In this work, we have studied how p38α down-regulation affects hepatocyte proliferation after partial hepatectomy, focusing on mitotic progression, cytokinesis and oxidative stress. We found that p38α deficiency triggered up-regulation of cyclins A1, B1, B2, and D1 under basal conditions and after hepatectomy. Moreover, p38α-deficient hepatocytes showed enhanced binucleation and increased levels of phospho-histone H3 but impaired phosphorylation of MNK1 after hepatectomy. The recovery of liver mass was transiently delayed in mice with p38α-deficient hepatocytes vs w

SUBMITTER: Rius-Perez S 

PROVIDER: S-EPMC6405944 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature