Intrauterine administration of peripheral mononuclear cells in recurrent implantation failure: a systematic review and meta-analysis.

ABSTRACT: It has been proposed that intrauterine administration of peripheral blood mononuclear cells (PBMCs) modulates maternal immune response through a cascade of cytokines, chemokines and growth factors to favor implantation. We conducted a meta-analysis to verify the effect of intrauterine PBMC administration on the outcome of embryo transfer in women with recurrent implantation failure (RIF). All relevant trials published in PubMed, Web of Science and Cochrane library databases were searched. Two randomized controlled trials and three cohort studies (1173 patients in total) matched the inclusion criteria. No differences in live birth rates were seen between the PBMC-treated patients and controls (OR: 1.65, 95% CI: 0.84-3.25; p = 0.14; I²: 66.3%). The clinical pregnancy rate was sign

SUBMITTER: Yakin K 

PROVIDER: S-EPMC6405957 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature