The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells.

ABSTRACT: Transcription factor networks, together with histone modifications and signalling pathways, underlie the establishment and maintenance of gene regulatory architectures associated with the molecular identity of each cell type. However, how master transcription factors individually impact the epigenomic landscape and orchestrate the behaviour of regulatory networks under different environmental constraints is only partially understood. Here, we show that the transcription factor Nanog deploys multiple distinct mechanisms to enhance embryonic stem cell self-renewal. In the presence of LIF, which fosters self-renewal, Nanog rewires the pluripotency network by promoting chromatin accessibility and binding of other pluripotency factors to thousands of enhancers. In the absence of LIF, Nanog bloc

SUBMITTER: Heurtier V 

PROVIDER: S-EPMC6406003 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature