A library of recombinant Babesia microti cell surface and secreted proteins for diagnostics discovery and reverse vaccinology.

ABSTRACT: Human babesiosis is an emerging tick-borne parasitic disease and blood transfusion-transmitted infection primarily caused by the apicomplexan parasite, Babesia microti. There is no licensed vaccine for B. microti and the development of a reliable serological screening test would contribute to ensuring the safety of the donated blood supply. The recent sequencing of the B. microti genome has revealed many novel genes encoding proteins that can now be tested for their suitability as subunit vaccine candidates and diagnostic serological markers. Extracellular proteins are considered excellent vaccine candidates and serological markers because they are directly exposed to the host humoral immune system, but can be challenging to express as soluble recombinant proteins. We have recently develop

SUBMITTER: Elton CM 

PROVIDER: S-EPMC6406021 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature