Integrated network analysis of transcriptomic and protein-protein interaction data in taurine-treated hepatic stellate cells.

ABSTRACT:

Background

Studies show that the antifibrotic mechanism of taurine may involve its inhibition of the activation and proliferation of hepatic stellate cells (HSCs). Since the molecular mechanism of taurine-mediated antifibrotic activity has not been fully unveiled and is little studied, it is imperative to use "omics" methods to systematically investigate the molecular mechanism by which taurine inhibits liver fibrosis.

Aim

To establish a network including transcriptomic and protein-protein interaction data to elucidate the molecular mechanism of taurine-induced HSC apoptosis.

Methods

We used microarrays, bioinformatics, protein-protein interaction (PPI) network, and sub-modules to investigate taurine-induced changes in gene expression in human HSCs (LX-2). Subs

SUBMITTER: Liang XQ 

PROVIDER: S-EPMC6406182 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature