Genomic Variations in Susceptibility to Intracranial Aneurysm in the Korean Population.

ABSTRACT: Genome-wide association studies found genetic variations with modulatory effects for intracranial aneurysm (IA) formations in European and Japanese populations. We aimed to identify the susceptibility of single nucleotide polymorphisms (SNPs) to IA in a Korean population consisting of 250 patients, and 294 controls using the Asian-specific Axiom Precision Medicine Research Array. Twenty-nine SNPs reached a genome-wide significance threshold (5 × 10^-8). The rs371331393 SNP, with a stop-gain function of ARHGAP32 (11q24.3), showed the most significant association with the risk of IA (OR = 43.57, 95% CI: 21.84⁻86.95; p = 9.3 × 10^-27). Eight out of 29 SNPs-GBA (rs75822236), TCF24 (rs112859779), OLFML2A (rs79134766), ARHGAP32 (rs371

SUBMITTER: Hong EP 

PROVIDER: S-EPMC6406302 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature