Targeting the Hedgehog Pathway in Cancer: Current Evidence and Future Perspectives.

ABSTRACT: The Hedgehog pathway (HhP) plays an important role in normal embryonic development and its abnormal function has been linked to a variety of neoplasms. Recently, the complex mechanisms involved in this pathway have been deciphered and the cross talks with other important pathways involved in carcinogenesis have been characterized. This knowledge has led to the development of targeted therapies against key components of HhP, which culminated in the approval of vismodegib for the treatment of advanced basal cell carcinoma in 2012. Since then, other compounds have been developed and evaluated in preclinical and clinical studies with interesting results. Today, several medications against components of the HhP have demonstrated clinical activity as monotherapies and in combination with cytotox

SUBMITTER: Girardi D 

PROVIDER: S-EPMC6406365 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature