AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis.

ABSTRACT: Aquaporin 1 (AQP1), expressed in epithelial cells of the choroid plexus, and aquaporin 4 (AQP4) present in ependymal cells and glia limitants have been proposed to play a significant role in cerebrospinal fluid (CSF) production and homeostasis. However, the specific contribution of each water channel to these functions remains unknown, being a subject of debate during the last years. Here, we analyzed in detail how AQP1 and AQP4 participate in different aspects of the CSF homeostasis such as the load and drainage of ventricles, and further explored if these proteins play a role in the ventricular compliance. To do that, we carried out records of intraventricular pressure and CSF outflow, and evaluated ventricular volume by magnetic resonance imaging in AQP1^-/-, AQP4^-/-

SUBMITTER: Trillo-Contreras JL 

PROVIDER: S-EPMC6406452 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature