White matter abnormalities in depression: A categorical and phenotypic diffusion MRI study.

ABSTRACT: Mood depressive disorder is one of the most disabling chronic diseases with a high rate of everyday life disability that affects 350 million people around the world. Recent advances in neuroimaging have reported widespread structural abnormalities, suggesting a dysfunctional frontal-limbic circuit involved in the pathophysiological mechanisms of depression. However, a variety of different white matter regions has been implicated and is sought to suffer from lack of reproducibility of such categorical-based biomarkers. These inconsistent results might be attributed to various factors: actual categorical definition of depression as well as clinical phenotype variability. In this study, we 1/ examined WM changes in a large cohort (114 patients) compared to a healthy control group and 2/ sough

SUBMITTER: Coloigner J 

PROVIDER: S-EPMC6406626 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature