Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer.

ABSTRACT: Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers. Moreover, aberrant histone ubiquitination can drive oncogenesis by altering the expression of tumor suppressors and oncogenes, misregulating cellular differentiation and promoting cancer cell proliferation. Thus, targeting aberrant histone ubiquitination may be a viable strategy to reprogram transcription in cancer cells, in order to halt cellular proliferation and induce cell death, which is the basis for the ongoing development of therapies targeting histone ubiquitination. In this review, we present the normal functions of histone H2A and H2B ubiq

SUBMITTER: Jeusset LM 

PROVIDER: S-EPMC6406838 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature