Systematic Review of the Potential of MicroRNAs in Diffuse Large B Cell Lymphoma.

ABSTRACT: Diffuse large B cell lymphoma (DLBCL) is the most common subtype of invasive non-Hodgkin's lymphoma (NHL). DLBCL presents with variable backgrounds, which results in heterogeneous outcomes among patients. Although new tools have been developed for the classification and management of patients, 40% of them still have primary refractory disease or relapse. In addition, multiple factors regarding the pathogenesis of this disease remain unclear and identification of novel biomarkers is needed. In this context, recent investigations point to microRNAs as useful biomarkers in cancer. The aim of this systematic review was to provide new insight into the role of miRNAs in the diagnosis, classification, treatment response and prognosis of DLBCL patients. We used the following terms in PubMed" (('No

SUBMITTER: Larrabeiti-Etxebarria A 

PROVIDER: S-EPMC6406874 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature