Ontology highlight
ABSTRACT:
SUBMITTER: Dong P
PROVIDER: S-EPMC6406952 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Dong Peixin P Xiong Ying Y Yue Junming J J B Hanley Sharon S Kobayashi Noriko N Todo Yukiharu Y Watari Hidemichi H
Cancers 20190216 2
Recent studies have revealed both the promise and challenges of targeting long non-coding RNAs (lncRNAs) to diagnose and treat endometrial cancer (EC). LncRNAs are upregulated or downregulated in ECs compared to normal tissues and their dysregulation has been linked to tumor grade, FIGO stage, the depth of myometrial invasion, lymph node metastasis and patient survival. Tumor suppressive lncRNAs (GAS5, MEG3, FER1L4 and LINC00672) and oncogenic lncRNAs (CCAT2, BANCR, NEAT1, MALAT1, H19 and Linc-R ...[more]