The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock.

ABSTRACT: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host-response to infections. Osteopontin (OPN) is an extracellular matrix protein involved in the inflammatory response. Our aim was to evaluate the diagnostic and prognostic performance in sepsis of a single OPN determination in the Emergency Department (ED). We conducted a single-centre prospective observational study in an Italian ED where we enrolled 102 consecutive patients presenting with suspected infection and qSOFA ≥ 2. OPN plasma concentration was found to be an independent predictor of sepsis (OR = 1.020, 95% CI 1.002⁻1.039, P = 0.031) and the diagnostic receiver operating characteristic (ROC) curve resulted in an area under the curve (AUC) of 0.878. OPN levels were positively correlated to plasma cre

SUBMITTER: Castello LM 

PROVIDER: S-EPMC6407102 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature