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Pre- and postnatal exposure of mice to concentrated urban PM_2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life.

ABSTRACT: Gestational exposure to air pollution is associated with negative outcomes in newborns and children. In a previous study, we demonstrated a synergistic negative effect of pre- and postnatal exposure to PM_2.5 on lung development in mice. However, the means by which air pollution affects development of the lung have not yet been identified. In this study, we exposed pregnant BALB/c mice and their offspring to concentrated urban PM_2.5 (from São Paulo, Brazil; target dose 600 μg/m³ for 1 h daily). Exposure was started on embryonic day 5.5 (E5.5, time of placental implantation). Lung tissue of fetuses and offspring was submitted to stereological and transcriptomic analyses at E14.5 (pseudoglandular stage of lung development), E18.5 (saccular stage) and P40 (post

SUBMITTER: de Barros Mendes Lopes T

PROVIDER: S-EPMC6407120 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Dataset Information

Pre- and postnatal exposure of mice to concentrated urban PM_2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life.

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Dataset Information

Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Pre- and postnatal exposure of mice to concentrated urban PM_2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life.