Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration.

ABSTRACT:

Background

The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous system are mediated by CB₁ receptors, which can elicit psychotropic effects, but other targets devoid of psychotropic activity, including CB₂ and nuclear PPARγ receptors, can also be the target of specific cannabinoids.

Methods

We investigated the pro-neurogenic potential of the synthetic cannabigerol derivative, VCE-003.2, in striatal neurodegeneration by using adeno-associated viral expression of mutant huntingtin in vivo and mouse embryonic stem cell differentiation in vitro.

Results

Oral administration of VCE-003

SUBMITTER: Aguareles J 

PROVIDER: S-EPMC6407204 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature