MFAP5 promotes basal-like breast cancer progression by activating the EMT program.

ABSTRACT:

Purpose

Human basal-like breast cancer (BLBC) is an aggressive malignancy with poor prognosis. Since most current treatments are ineffective, there is an urgent need to identify therapeutic targets for BLBC. Microfibrillar-associated protein 5 (MFAP5) plays an important role in the integration of elastic microfibers and the regulation of endothelial cell behaviors. We previously demonstrated that MFAP5 was significantly overexpressed in BLBC tissues and associated with poor metastasis-free survival of patients with BLBC. However, the detailed role of MFAP5 in BLBC is unclear. Thereby, the current study aimed to investigate the underlying function of MFAP5 in BLBC.

Method

Functional analyses were conducted for the role of MFAP5 in BLBC in vitro and in vivo.

Results

Ove

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6407223 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature