GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer.

ABSTRACT:

Background

Triple-negative breast cancers (TNBCs), which lack receptors for estrogen, progesterone, and amplification of epidermal growth factor receptor 2, are highly aggressive. Consequently, patients diagnosed with TNBCs have reduced overall and disease-free survival rates compared to patients with other subtypes of breast cancer. TNBCs are characterized by the presence of cancer cells with mesenchymal properties, indicating that the epithelial to mesenchymal transition (EMT) plays a major role in the progression of this disease. The EMT program has also been implicated in chemoresistance, tumor recurrence, and induction of cancer stem cell (CSC) properties. Currently, there are no targeted therapies for TNBC, and hence, it is critical to identify the novel targets to treat TNBC

SUBMITTER: Vijay GV 

PROVIDER: S-EPMC6407242 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature