Eosinophil-cationic protein - a novel liquid prognostic biomarker in melanoma.

ABSTRACT:

Background

The role of eosinophils in cancer is not yet completely understood, but patients with eosinophilia show a trend towards longer survival in several types of cancer, including melanoma. However, eosinophil count at initial diagnosis of metastatic melanoma does not predict survival. Since eosinophil cationic protein (ECP) mediates anticancer effects, such as tissue remodelling and cytotoxic activity, we investigated this marker as an early prognostic marker in metastatic melanoma.

Methods

Serum of 56 melanoma patients was collected at the time of diagnosis of metastatic disease. ECP levels as measured by ELISA were correlated with overall survival (OS) in patients before systemic therapy with immunotherapy or chemotherapy. Statistical analyses were performed using th

SUBMITTER: Kruckel A 

PROVIDER: S-EPMC6407264 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature