Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) represents an aggressive subtype with limited therapeutic options. Experimental preclinical models that recapitulate their tumors of origin can accelerate target identification, thereby potentially improving therapeutic efficacy. Patient-derived xenografts (PDXs), due to their genomic and transcriptomic fidelity to the tumors from which they are derived, are poised to improve the preclinical testing of drug-target combinations in translational models. Despite the previous development of breast and TNBC PDX models, those derived from patients with demonstrated health-disparities are lacking.

Methods

We use an aggressive TNBC PDX model propagated in SCID/Beige mice that was established from an African-American woman, TU-BcX-2 K1,

SUBMITTER: Matossian MD 

PROVIDER: S-EPMC6407287 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature