Age-related oxidative stress confines damage-responsive Bmi1⁺ cells to perivascular regions in the murine adult heart.

ABSTRACT: Adult progenitor cells reside in specialized microenvironments which maintain their undifferentiated cell state and trigger regenerative responses following injury. Although these environments are well described in several tissues, the cellular components that comprise the cardiac environment where progenitor cells are located remain unknown. Here we use Bmi1^CreERT and Bmi1^GFP mice as genetic tools to trace cardiac damage-responsive cells throughout the mouse lifespan. In adolescent mice, Bmi1⁺ damage-responsive cells are broadly distributed throughout the myocardium. In adult mice, however, Bmi1⁺ cells are confined predominately in perivascular areas with low levels of reactive oxygen species (ROS) and their number decline in an age-dependent ma

SUBMITTER: Herrero D 

PROVIDER: S-EPMC6407305 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature