Resistance mechanisms and reprogramming of microorganisms for efficient biorefinery under multiple environmental stresses.

ABSTRACT: In the fermentation process of biorefinery, industrial strains are normally subjected to adverse environmental stresses, which leads to their slow growth, yield decline, a substantial increase in energy consumption, and other negative consequences, which ultimately seriously hamper the development of biorefinery. How to minimize the impact of stress on microorganisms is of great significance. This review not only reveals the damaging effects of different environmental stresses on microbial strains but also introduces commonly used strategies to improve microbial tolerance, including adaptive evolution, reprogramming of the industrial host based on genetic circuits, global transcription machinery engineering (gTME) and bioprocess integration. Furthermore, by integrating the advantages of th

SUBMITTER: Xu K 

PROVIDER: S-EPMC6407310 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature