Cortical volume and 40-Hz auditory-steady-state responses in patients with schizophrenia and healthy controls.

ABSTRACT:

Background

Abnormalities in the 40-Hz auditory steady-state response (ASSR) of the gamma range have been reported in schizophrenia (SZ) and are regarded as important pathophysiological features. Many of the previous studies reported diminished gamma oscillations in SZ, although some studies reported increased spontaneous gamma oscillations. Furthermore, brain morphological correlates of the gamma band ASSR deficits have rarely examined. We investigated different measures of the 40-Hz ASSR and their association with brain volumes and psychological measures of SZ.

Methods

The 40-Hz ASSR was measured for 80 dB click sounds (1 ms, 500-ms trains at 40-Hz, with 3050 to 3500 inter-train interval) using electroencephalography with 64 electrodes in 33 patients with SZ (male: 16, fema

SUBMITTER: Kim S 

PROVIDER: S-EPMC6407311 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature