A single extra copy of Down syndrome critical region 1-4 results in impaired hepatic glucose homeostasis.

ABSTRACT:

Objectives

During fasting, hepatic gluconeogenesis is induced to maintain energy homeostasis. Moreover, abnormal dysregulation of hepatic glucose production is commonly observed in type 2 diabetes. However, the signaling components controlling hepatic glucose production to maintain normal glucose levels are not fully understood. Here, we examined the physiological role of Down syndrome critical region 1-4 (DSCR1-4), an endogenous calcineurin signaling inhibitor in the liver that mediates metabolic adaptation to fasting.

Methods

We assessed the effect of cyclosporine A, an inhibitor of calcineurin signaling on gluconeogenic gene expression in primary hepatocytes. DSCR1-4 expression was examined in diet- and genetically-induced mouse models of obesity. We also investigated the

SUBMITTER: Seo DS 

PROVIDER: S-EPMC6407364 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature