Differential Function of Melatonin MT₁ and MT₂ Receptors in REM and NREM Sleep.

ABSTRACT: The pathophysiological function of the G-protein coupled melatonin MT₁ and MT₂ receptors has not yet been well-clarified. Recent advancements using selective MT₁/ MT₂ receptor ligands and MT₁/MT₂ receptor knockout mice have suggested that the activation of the MT₁ receptors are mainly implicated in the regulation of rapid eye movement (REM) sleep, whereas the MT₂ receptors selectively increase non-REM (NREM) sleep. Studies in mutant mice show that MT₁ knockout mice have an increase in NREM sleep and a decrease in REM sleep, while MT2 knockout mice a decrease in NREM sleep. The localization of MT₁ receptors is also distinct from MT2 receptors; for example, MT₂ receptors a

SUBMITTER: Gobbi G 

PROVIDER: S-EPMC6407453 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature