Genome-wide Significance Thresholds for Admixture Mapping Studies.

ABSTRACT: Admixture mapping studies have become more common in recent years, due in part to technological advances and growing international efforts to increase the diversity of genetic studies. However, many open questions remain about appropriate implementation of admixture mapping studies, including how best to control for multiple testing, particularly in the presence of population structure. In this study, we develop a theoretical framework to characterize the correlation of local ancestry and admixture mapping test statistics in admixed populations with contributions from any number of ancestral populations and arbitrary population structure. Based on this framework, we develop an analytical approach for obtaining genome-wide significance thresholds for admixture mapping studies. We validate o

SUBMITTER: Grinde KE 

PROVIDER: S-EPMC6407497 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature