Risk of Upper Gastrointestinal Bleeding and Gastroduodenal Ulcers in Persons With Schizophrenia: A Danish Cohort Study.

ABSTRACT:

Introduction

There is little evidence about gastrointestinal (GI) disorders in patients with schizophrenia. We examined association of schizophrenia with upper GI bleeding (UGIB) and nonbleeding ulcers and associated risk factors and mortality.

Methods

We used the data linked from population-based registries in Denmark. Among patients with incident schizophrenia in 1980-2011, we computed cumulative incidences and standardized incidence ratios of UGIB, bleeding ulcers, and nonbleeding ulcers compared with the general population; evaluated risk factors for the 3 GI endpoints, including somatic and psychiatric comorbidity; and examined subsequent all-cause mortality.

Results

Among 39,998 patients with schizophrenia, the standardized incidence ratios were 2.92 (95% confid

SUBMITTER: Cotton CC 

PROVIDER: S-EPMC6407813 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature