Chromatic pupilloperimetry for objective diagnosis of Best vitelliform macular dystrophy.

ABSTRACT:

Purpose

To determine the pupil response of Best vitelliform macular dystrophy (BVMD) patients for focal blue and red light stimuli presented at 76 test points in a 16.2° visual field (VF) using a chromatic pupilloperimeter.

Methods

An observational study was conducted in 16 participants: 7 BVMD patients with a heterozygous BEST1 mutation and 9 similar-aged controls. All participants were tested for best-corrected visual acuity, chromatic pupilloperimetry and Humphrey perimetry. Percentage of pupil contraction (PPC), maximal pupil contraction velocity (MCV) and latency of MCV (LMCV) were determined.

Results

The mean PPC and MCV recorded in BVMD patients in response to red stimuli were lower by >2 standard errors (SEs) from the mean of controls in 47% and 43% of VF test

SUBMITTER: Ben Ner D 

PROVIDER: S-EPMC6407903 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature