Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products.

ABSTRACT:

Background

No systematic investigations have been conducted to assess the lung burden imposed by the chronic inhalation of silver nanoparticles (AgNPs) emitted by spray products.

Objective

The objective of this study was to formulate a study framework that integrates a probabilistic risk assessment scheme with a mechanistic lung burden model for the estimation of health risks associated with the long-term inhalation of AgNP-containing spray products.

Materials and methods

A compartmentalized physiologically based alveolar deposition (PBAD) model was used to estimate AgNP lung burden. Dose-response relationships were established using nanotoxicity data sets obtained from rats (as a model organism). Weibull model-based thresholds of AgNP lung burden based on neutrophil-

SUBMITTER: Yang YF 

PROVIDER: S-EPMC6407905 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature