Cross-ID: Analysis and Visualization of Complex XL-MS-Driven Protein Interaction Networks.

ABSTRACT: Protein interactions enable much more complex behavior than the sum of the individual protein parts would suggest and represents a level of biological complexity requiring full understanding when unravelling cellular processes. Cross-linking mass spectrometry has emerged as an attractive approach to study these interactions, and recent advances in mass spectrometry and data analysis software have enabled the identification of thousands of cross-links from a single experiment. The resulting data complexity is, however, difficult to understand and requires interactive software tools. Even though solutions are available, these represent an agglomerate of possibilities, and each features its own input format, often forcing manual conversion. Here we present Cross-ID, a visualization platform t

SUBMITTER: de Graaf SC 

PROVIDER: S-EPMC6407916 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature